Bone Abstracts

During the differentiation of the osteoclast, it transform from a mono-nucleated cell to multinucleated cell by fusion of its precursors. Although, cell fusion is a complicated process which likely involves many regulating proteins, only a few osteoclast fusion regulating proteins were identified. We have identified dual-specificity tyrosine-phosphorylation regulated kinase 2 (Dyrk2) as a novel regulator of the osteoclast fusion process. Dyrk2 belongs to a family of protein ki...

G-protein coupled receptors (GPCRs) are the largest family of cell surface proteins, which are important for bone development, remodeling and diseases. One of the GPCRs, called GPR39, has been found to be expressed in several osteoblastic cell lines. However, its role in bone metabolism has not been investigated yet. In order to elucidate a role for GPR39, we characterized the bone phenotype in GPR39 deficient mice. During aging, at six months old, dynamic histomorphometry dat...